Submicroscopic deletions in the Y chromosome of infertile men
نویسندگان
چکیده
منابع مشابه
Molecular Study of Partial Deletions of AZFc Region of the Y Chromosome in Infertile Men
Background & Aims: The most significant cause of infertility in men is the genetic deletion in the azoospermia factor (AZF) region that is caused by the process of intra- and inter-chromosomal homologous recombination in amplicons. Homologous recombination could also result in partial deletions in AZF region. The aim of this research was to determine the association between the partial AZFc del...
متن کاملSUBMICROSCOPIC DELETIONS OF THE Y CHROMOSOME ARE NOT LIMITED TO AZOOSPERMIC MEN, BUT ARE ALSO DETECTED IN INFERTILE MEN WITH IDIOPATHIC OLIGOZOOSPERMIA
It is now agreed that 10-25% of infertile men with azoospermia have submicroscopic deletions of the Y chromosome long ann (yq), consistent with the proposed location of the azoospermia locus (AZF) in Yq 11.23. However, it is not known whether Yq microdeletions are unique to men with azoospermia or whether they are also observed in infertile men with less severe defects of spermatogenesis (o...
متن کاملsubmicroscopic deletions of the y chromosome are not limited to azoospermic men, but are also detected in infertile men with idiopathic oligozoospermia
it is now agreed that 10-25% of infertile men with azoospermia have submicroscopic deletions of the y chromosome long ann (yq), consistent with the proposed location of the azoospermia locus (azf) in yq 11.23. however, it is not known whether yq microdeletions are unique to men with azoospermia or whether they are also observed in infertile men with less severe defects of spermatogenesis (oligo...
متن کاملthe prevalence of y chromosome microdeletions in pakistani infertile men
background: microdeletions of the azoospermia factor locus of the long arm of y chromosome are an etiological factor of severe oligozoospermia or azoospermia. objective: the aim of this study was to investigate the prevalence of y-chromosome microdeletions in azf region and their role in infertility in pakistani population. materials and methods: the type of deletions in azf locus were detected...
متن کاملA simplified gene-specific screen for Y chromosome deletions in infertile men.
OBJECTIVE To test the diagnostic efficiency of a gene-specific, five-marker screening strategy for the detection of Y chromosome deletions. DESIGN Prospective case study. SETTING University genetics laboratory and reproductive clinics. PATIENT(S) Six hundred twenty-seven infertile men and 212 fertile men. INTERVENTION(S) Peripheral blood samples were screened for Y chromosome deletions ...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 1997
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/12.8.1635